As of July 2026, the population of Sao Tome and Principe is 245 thousand. The number of inhabitants has increased by 5 thousand in the last year, representing a growth of 1.97%. The median age of the population has increased in recent years, rising from 17.9 years in 2016 to 19.7 years in 2026. Currently, life expectancy at birth is 70.3 years and population density is 255.2 inhabitants per square kilometer.
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The population growth rate of Sao Tome and Principe peaked in 1978, reaching around 2.7% annually, but has since declined to approximately 1.94% in 2026. The annual increase in the number of people has also decreased from a peak of around 4.87 thousand in 2020 to nearly 4.75 thousand in 2026.
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In Sao Tome and Principe, life expectancy at birth has been increasing, with the indicator rising from 63 years in 2006 to 70.3 years in 2026, representing an increase of more than 7 years over the past 2 decades.
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The cities of Sao Tome and Principe are small, with the 5 most populated adding up to around 80.5 thousand inhabitants. The most populous city is São Tomé, São Tomé Island, con una diferencia significativa sobre las demás, alcanzando approximately 53.3 thousand inhabitants. It is followed by Neves, São Tomé Island with 8.4 thousand and Água Izé, São Tomé Island with 7.4 thousand.
These are the 20 most populous cities in Sao Tome and Principe:
| # | City | Population |
|---|---|---|
| 1 | São Tomé, São Tomé Island | 53,300 |
| 2 | Neves, São Tomé Island | 8,391 |
| 3 | Água Izé, São Tomé Island | 7,445 |
| 4 | Folha Fede, São Tomé Island | 6,685 |
| 5 | Riboque, São Tomé Island | 4,640 |
| 6 | Almas, São Tomé Island | 4,601 |
| 7 | Pantufo, São Tomé Island | 3,977 |
| 8 | Dona Eugénia, São Tomé Island | 3,605 |
| 9 | São Marçal, São Tomé Island | 2,866 |
| 10 | Rosema, São Tomé Island | 2,587 |
| # | City | Population |
|---|---|---|
| 11 | Agua Porca, São Tomé Island | 2,048 |
| 12 | Bombom, Príncipe | 1,754 |
| 13 | Almeirim, São Tomé Island | 1,591 |
| 14 | Piedade, São Tomé Island | 1,408 |
| 15 | Micolo, São Tomé Island | 1,404 |
| 16 | Ribeira Afonso, São Tomé Island | 1,300 |
| 17 | Changra, São Tomé Island | 1,224 |
| 18 | Santo António, Príncipe | 1,156 |
| 19 | Lemos, São Tomé Island | 1,136 |
| 20 | Santo Amaro, São Tomé Island | 1,063 |